As a real life fat slob, I am the perfect specimen to test food reward religious doctrine.
All weekend (who am I kidding, the past few days) I have been eating like a major chunky butt. Like just eating TONS AND TONS. Eating so much, that when I go to sleep and stop eating, I am completely nauseated when I wake up.
Unfortunately today is also unofficial mothers day for mi familia; yesterday was mothers day but none of us were available until today to take mommy for her dinner, so we took her tonight to a restaurant for our annual gift carding and feeding hallmark card sponsored american celebration. Social eating, mandated, no real way out of it. We arrive at the restaurant rather like the hillbilly welcome wagon: laughing, making jokes, ranting and mockery, it was not unlike a dinner table full of woo x 4. I sorta felt bad for the wait staff as we might have scared them a bit.
So, sitting at the table I try to "order". I am
TOTALLY not hungry at all, the food looks disgusting, I am actively experiencing nausea, and the reason for this is the fact i ate so much the past few days and am presently fasting. Here is a simple diagram to explain the endocrine and metabolic state I am experiencing:
LOW INSULIN + HIGH LEPTIN / FFA / GLUCOSE =
puuuuuuuke ew food never want/ need to eat again
everything looks pretty gross even cake and cookies even cheese
even chips even fried things with crusts
ugh vomit!
no want!
blech!
:(
Of course I really can't order anything and the only things I want are the lightest, least caloric things I can think of. Shrimp cocktail sounds not that gross. Maybe scallops and vegetables. I can probably eat that w/o feeling sick.
Ordinarily I would be drinking the grease from steaks and dipping chicken wings in cheese and sour cream and that would sound pretty awesome...but ordinarily I am not comming off of a week of 2300 calories per day, either. So in this present condition the only thing I can even think of eating, are the sorts of meals naturally obesity resistant, underweight anoretic graduate students eat and feel completely satisfied on.
I sit and suspect the way I feel now might be, and probably is, the way anoretic women, people like stephan guyenet, and the various other "mentally ill thin" feel every single day. Can't tolerate fat. Can't desire food. Only capable of consuming low fat caloric sparse meals, due to nervous system that is violently rejecting nutrition and refusing to grow fatter. A piece of fruit and a little lean fish is all that we can deal with right now. High serotonin, high NE, higher peripheral and central dopamine, and fat tissue that is just simply not having it; lots of fat oxidation at rest, leading to a "talk to the hand, insulin" kind of situation. The nausea is directly related to nervous system changes: more serotonin, more dopamine.
GUESS WHAT ZOFRAN DOES? Blocks serotonin.
GUESS WHAT VIRTUALLY ALL OTHER ANTI- VOMMY MEDICATIONS DO? Block dopamine.
Metoclopramide:
-Works to stop nausea and vomitting
-
Helps psychosis, but never used for this indication
-Will cause psychotic symptoms as a drug tolerance symptom (
cool story brah!)
-Causes elevation of prolactin and endocrine disorders
-Causes EPS / parkinsonian symptoms / MH and of course
weight gain (ps I like this pt anecdote because the condition was treated effectively but no weight gain occurred; it only occurred when the dose was raised to bolster the dopamine/serotonin blockade to haldolian / seroquelian oppressiveness. Certain morons might be apt to argue that treating intestinal disorders is the real cause of weight gain, whereas this case provides evidence that is not true and there is a specific effect of metoclopramide to gain weight)
wut you mean,
DOPAMINE??!!
you mean it helps prevents the fatness????
and blocking it actively induces the fatness!?
This blasphemy runs completely counter to Father Guyenets sermons! Father Guyenet has spent great blood sweat and tears helping us lost powdered nacho cheese covered masses learn the truth.
Dopamine promotes obesity by driving eating behavior! Food that is varied in taste, texture, and flavor, and incentivizing, causes a release of excessive and inappropriately elevated CNS dopamine, which keeps us always transfixed with eating. How then can it be true that the post-overfed fasting state is actively hallmarked by signs of excessive dopamine, such as nausea... meanwhile, dopamine blocking medications (whether indicated for nausea or indicated for psychosis, whether peripherally acting or centrally or both) actively CAUSE WEIGHT GAIN?? BLASPHEMER!!!! ANTI-SCIENCE AGAINST CONSENSUS OF THE RESEARCH!!!
So, anyway. Let it be known I was sitting at this table full of pukes and yucks, in my post hypercaloric, post fasting state (low insulin, high leptin).
...but then I ate some paleo potato chips.
After about a few minutes, as long as it takes for insulin to rise and respond to nutrition, the nausea was gone. Not only was the nausea gone, but the disinterest in eating was as well. I wasn't necessarily hungry, but I wasn't repulsively full, either. Eating was no longer this horrifying repulsive proposition; with the help of paleo potatos, I could now easily consume an entire meal, in spite of the fact I was just severely averse to food even extremely palatable food just a few minutes earlier.
With a few bites of some tortilla chips, I was now relatively in a higher insulin condition. I was no longer oxidizing body fat at a high rate, I was no longer with high level of FFA for energy from my own fat tissue; I was now using more glucose for energy and not using fat for energy, and this promotes rational hunger.
Obesity resistant people find it extremely easy to oxidize body fat, and that is the difference between people like me and people who are naturally anoretics (e.g. AN females, S. Guyenet). My body will pretty much completely and absolutely terminate body fat oxidation at trivial insulin concentrations (as well as induct drops in FFA/glucose). This is likely secondary to obesity-specific defects: fat tissue insulin supersensitivity, SNS deficits in the fat tissue, adipocyte hyperplasia, and so on. The risk factors for certain types of "metabolically healthy" obesity are actually , ironically, often times inverse of the risk factors for diabetes mellitus (we make LOTS of insulin whereas diabetics eventually develop insulin deficiency... we EASILY suppress FFA/glucose and succumb to frequent energy instability and fasting intolerance...our fat tissue is like SHUT UP AND SIT DOWN when dealing with using itself for energy). This is because diabetes mellitus is actually the metabolic opposite of obesity, in spite of popular religiously influenced misconception. However, the ironic truth that the former (obesity) often results in the latter (diabetes). Maximum genetically determined capacity for white fat tissue growth, will naturally translate into an onset of diabetes mellitus, and there is absolutely no swifter way to induce diabetes-like metabolic pathology as terminating , ablating, adipocytes (which is metabolically virtually the same thing as maximum adipocyte maturation and distention BTW).
For someone like myself, a HYPER FAT TRUCK in a weight reduced condition, trivial insulin, trivial glucose and carbohydrate, is enough to dramatically terminate the use of body fat for energy, along with FFA and glucose. This is in a way the polar opposite finding of diabetes but is rather significant for some kinds of met healthy obesities. Guess what happens when a hormone terminates sufficient energy availability? Hunger results, (and fat gain is very very easy over any long term trend of time)
I'm not a fool, so I know to keep it low carb in general (I only consumed a handful of chips, just enough to be capable of eating; the rest of my food intake was a few bites of steak, some scallops, some sour cream/butter, cauliflower, a few bites of beef chilli, a few ounces of cheese, and a few bites of cheesecake (ps, cheesecake isn't that terrible of a dessert option, even full sugar, if you only eat a tiny amount it's just a couple carbs).
So the meal didn't make me HUNGRY, but I was HUNGRY ENOUGH to eat it (but rapidly became full as the nutrition is much greater than the insulin / ability to store the nutrition given my baseline condition otherwise).
Clearly this episode serves as evidence that the rewarding properties of food promote obesity. Right? After all, I ate a full sized meal at a restaurant, devout followers of Guyenet would point out.
The food reward boy's choir (Chuck, Nige, et al) are liable to agree with that above facile, imbecilic interpretation. I'm sure many self hating obese people would also agree. Upon closer inspection, this is not at all what was observed.
- IN A FASTING STATE I was nauseated and not at all inclined to consume food in spite of it being present (which, hypothetically, should activate my defective "reward" circuitry, as I was privy to the smell and sight of various appetizing foods)
-
- IN A POST GLUCOSE EXPOSURE STATE, I only was only then able to consume food, after waiting a few minutes for my endocrine and metabolic state to transition into a glucose-fed condition. Take note, if I ate pure fat like butter or cream, I likely would have only exacerbated the nausea and food avoidance. I know because I've done it before. Meanwhile, a tortilla chip which I didn't even enjoy eating, allowed me to stop nausea and feel desire to consume food.
The ability to eat DID FOLLOW glucose procsessing / insulin increasing in my body.
The ability to eat DID NOT FOLLOW being exposed to the incentivizing, or convenience-related properties of food, such as observing several plates in front of me of freshly prepared diverse food items with smell and sight.
This is clear evidence , once more, "reward" is subordinate to the metabolic/nervous system state of the body, and so called "palatable" food ceases to be incentivizing (or even *possible* to successfully consume) if one's endocrine and metabolic state is completely oppositional to storing fat.
(BTW, I can't wait for the dullards to tell me I became hungry because the food in restaurant was rewarding ;D )